Hydrochloric Acid → HCID 55234162, compound

HRID 2112105Notes

Reaction equation

HRID 2112105 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O.Cl>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH2:19][CH2:20]2)[CH:6]=[CH:7][C:8]=1[NH2:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 63670490HCID 63670490, compound

Product 1

HCID 55234162HCID 55234162, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

200 mg (0.716 mmol) (3-methoxy-4-nitro-phenyl)-(3-pyrrolidin-1-yl-propyl)-amine are dissolved in 10 ml of methanol and combined with 537 μl (2.148 mmol) dioxanic hydrochloric acid and 20 mg palladium on charcoal. The reaction mixture is stirred for 1 h at ambient temperature and 5 bar H2 pressure. The catalyst is filtered off and the solvent is eliminated in vacuo.

Workup

  1. filtrationThe catalyst is filtered off

Sources & evidence

ORD record
ord-d8358bcd273d4e8d94122873bff73054
Source dataset
uspto-grants-2009_04
Patent number
US07521457B2

Reaction notes

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