Acetic Acid → HCID 57641202, compound

HRID 2112290Notes

Reaction equation

HRID 2112290 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[Cl:11][CH2:12][C:13](=[O:20])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].C(N)C1C=CC=CC=1.C(O)(=O)C>C(O)(C)C>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1/[CH:4]=[C:14](/[C:13](=[O:20])[CH2:12][Cl:11])\[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 7504BenzylamineHCID 134042,4-DichlorobenzaldehydeHCID 69484Ethyl 4-chloroacetoacetate

Product 1

HCID 57641202HCID 57641202, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution 2,4-dichlorobenzaldehyde (4.6 g, 26.1 mmol), ethyl 4-chloro-3-oxobutanoate (4.5 g, 27.4 mmol), benzylamine (165 mg, 1.5 mmol), and acetic acid (118 mg, 2.0 mmol) in isopropyl alcohol (30 mL) stirred at ambient temperature for 96 h. The mixture was diluted with isopropyl alcohol to give a total volume of 50 mL and was saved as a stock solution (0.52 mmol/mL).

Workup

  1. customto give a total volume of 50 mL

Sources & evidence

ORD record
ord-b6107026263f4f9d8b5857712fc175ed
Source dataset
uspto-grants-2009_04
Patent number
US07521557B2

Reaction notes

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