Trifluoroacetic acid → HCID 86608930, compound

HRID 2112409Notes

Reaction equation

HRID 2112409 reaction equation
C(OC([N:8]1[C:17]2=[CH:18][N:19]([C@@H:21]3[O:34][C@H:33]([CH2:35][O:36][C:37](=[O:39])[CH3:38])[C@@H:27]([O:28][C:29](=[O:32])[CH2:30][CH3:31])[C@H:22]3[O:23][C:24](=[O:26])[CH3:25])[N:20]=[C:15]3[C:16]2=[C:10]([C:11](=[O:40])[NH:12][N:13]=[CH:14]3)[C:9]1=[O:41])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:31][CH2:30][C:29]([O:28][C@@H:27]1[C@@H:33]([CH2:35][O:36][C:37](=[O:39])[CH3:38])[O:34][C@@H:21]([N:19]2[CH:18]=[C:17]3[NH:8][C:9](=[O:41])[C:10]4[C:11](=[O:40])[NH:12][N:13]=[CH:14][C:15]([C:16]=43)=[N:20]2)[C@@H:22]1[O:23][C:24](=[O:26])[CH3:25])=[O:32]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86608931HCID 86608931, compound

Product 1

HCID 86608930HCID 86608930, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Step 7 in DCM is cooled to 0° C., and TFA is added to the vigorously stirred mixture. The mixture is allowed to stir until product is sufficiently deboc'd as determined by TLC. The crude material is concentrated in vacuo and purified by flash chromatography to give the target compound.

Workup

  1. concentrationThe crude material is concentrated in vacuo
  2. custompurified by flash chromatography
  3. customto give the target compound

Sources & evidence

ORD record
ord-7436908863e242869b5bb9c59ff820b3
Source dataset
uspto-grants-2009_04
Patent number
US07524825B2

Reaction notes

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