Piperazine → 4-(1-Piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole

HRID 2112458Notes

Reaction equation

HRID 2112458 reaction equation
Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20])(=[O:13])=[O:12].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[N:21]1([C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[CH:4]=[CH:5][N:6]3[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])(=[O:13])=[O:12])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 220153344-Bromo-1-(2-methyl-benzenesulfonyl)-1H-indole

Product 1

HCID 101572994-(1-Piperazinyl)-1-(2-methylbenzenesulfonyl)-1H-indole

Procedure

The title compound was prepared from 4-bromo-1-(2-methyl-benzenesulfonyl)-1H-indole and piperazine according to Method 1 to give 25 mg (12%) of a white solid: 1NMR (CD3OD) δ 7.91-6.79 (m, 9H), 3.49-3.30 (m, 8H), 2.48 (s, 3H); MS (ESI) 356.1 (M+H)+; Purity (HPLC) >95%.

Sources & evidence

ORD record
ord-3c27076aadde4d0f94908982eda5cc26
Source dataset
uspto-grants-2009_04
Patent number
US07524839B2

Reaction notes

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