Hydrazine → HCID 178421676, compound

HRID 2112515Notes

Reaction equation

HRID 2112515 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:23])[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[CH:18][C:13]=2[NH:12][C:11](=S)[CH2:10][N:9]=1.CO[C:27](OC)([N:29](C)C)[CH3:28].[NH2:34]N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([F:23])[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[CH:18][C:13]=2[N:12]=[C:11]2[NH:34][NH:29][C:27]([CH3:28])=[C:10]2[N:9]=1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 57642389HCID 57642389, compound

Product 1

HCID 178421676HCID 178421676, compound

Procedure

5-(2-chlorophenyl)-1,2-dihydro-7-fluoro-8-(1-methylethoxy)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVh) was prepared by reacting 0.00198 moles of 5-(2-chlorophenyl)-1,3-dihydro-7-fluoro-8-(1-methylethoxy)-2H-1,4-benzodiazepin-2-thione (IIh) with 1,1-dimethoxy-N,N-dimethyl-ethanamine and then hydrazine in a manner analogous to Example 55. MH+/Z=385.

Sources & evidence

ORD record
ord-65ebdac3c57e4d0daa3f40843970e34e
Source dataset
uspto-grants-2009_04
Patent number
US07524840B2

Reaction notes

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