Hydrochloric Acid → HCID 68829855, compound

HRID 2112564Notes

Reaction equation

HRID 2112564 reaction equation
[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][C@@H:19]([F:21])[CH2:18][C@H:17]3[C:22]#[N:23])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1.[ClH:24]>CCOC(C)=O>[ClH:24].[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][C@@H:19]([F:21])[CH2:18][C@H:17]3[C:22]#[N:23])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11623906868771-57-7

Product 1

HCID 68829855HCID 68829855, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a stirred solution of Example 42 (250 mg, 0.80 mmol) in EtOAc (3 ml) was added a saturated solution of dry HCl in EtOAc (2 ml). This solution was stirred at RT for 30 min to result a white precipitate. The product was collected by filtration and dried under vacuum to give 279 mg of the product as a white solid; 1H NMR (D2O, 300 MHz) δ 1.41-1.62 (m, 2H), 1.75-1.87 (m, 2H), 2.02-2.17 (m, 2H), 2.27-2.74 (m, 4H), 3.67-4.20 (m, 4H), 4.41 (d, J=6.9 Hz, 2H), 5.00-5.15 (m, 1H), 5.43-5.60 (m, 1H), 8.52 (s, 1H), 9.27 (s, 1H).

Workup

  1. customto result a white precipitate
  2. filtrationThe product was collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-6beb36819638466a95ea081a57f3bad7
Source dataset
uspto-grants-2009_04
Patent number
US07524844B2

Reaction notes

Loading…