反应详情

To 10 mL of methyl alcohol in a sealed tube is added sodium hydride (440 mg, 11 mmol) with stirring. 1-Methyl-2-imidazole carbonitrile (1.18 g, 11 mmol) is added. The mixture is stirred at room temperature for 20 h, and ammonium chloride (588 mg, 11 mmol) is added. The bottle is then sealed and stirred at 80° C. for 8 h, and cooled to room temperature. The mixture is filtered, and the filtrate is concentrated. The residue is treated with 1% methyl alcohol in diethyl ether, and the precipitates are collected by filtration and dried to give 1-methyl-2-imidazole carboxamidine hydrochloride as a gray solid (1.6 g). MS: m/z 125.2 (M+H).

1. stirringThe mixture is stirred at room temperature for 20 h
2. customThe bottle is then sealed
3. stirringstirred at 80° C. for 8 h
4. filtrationThe mixture is filtered
5. concentrationthe filtrate is concentrated
6. additionThe residue is treated with 1% methyl alcohol in diethyl ether
7. filtrationthe precipitates are collected by filtration
8. customdried