Hydrochloric Acid → HCID 11329511, compound

HRID 2112837Notes

Reaction equation

HRID 2112837 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2([OH:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[C:23]1([CH2:29][CH:30]=O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[ClH:32]>>[ClH:1].[ClH:32].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2([OH:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:30][CH2:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 998PhenylacetaldehydeHCID 103815021-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Product 1

HCID 11329511HCID 11329511, compound

Procedure

In an analogous manner to Example 117,1-{1-(3-chlorophenyl)-2-[4-(2-phenylethyl)piperazin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 1) and phenylacetaldehyde. MS (ESI) m/z 427/429 ([M+H]+); HRMS: calcd for C26H35ClN2O.2.00 HCl, 498.1971; found (ESI), 427.2505.

Sources & evidence

ORD record
ord-d814d7423c374d6487046e60ac1c8d6a
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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