Hydrochloric Acid → HCID 23085394, compound

HRID 2112880Notes

Reaction equation

HRID 2112880 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[N:7]=[C:6]1Cl)[C:2]#[C:3][CH3:4].C([O-])(=[O:19])C.[Na+].C(=O)(O)[O-].[Na+].Cl>CS(C)=O.O>[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[NH:7][C:6]1=[O:19])[C:2]#[C:3][CH3:4]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 517045Sodium AcetateHCID 23070643HCID 23070643, compound

Product 1

HCID 23085394HCID 23085394, compoundYield 85.7%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

7-(2-Butynyl)-2,6,8-trichloro-7H-purine (1.0 g) was dissolved in dimethylsulfoxide (20 mL), and then sodium acetate (595 mg) and sodium bicarbonate (366 mg) were added to the mixture. This reaction solution was stirred at room temperature for 12 hours, and then 1 N of aqueous hydrochloric acid solution (5.0 mL) and 80 mL of water were added. This reaction solution was stirred at room temperature for one hour, and then a white precipitate was collected by filtration. The white solid obtained was washed with water and t-butyl methyl ether to give the title compound (800 mg).

Workup

  1. stirringThis reaction solution was stirred at room temperature for one hour
  2. filtrationa white precipitate was collected by filtration
  3. customThe white solid obtained
  4. washwas washed with water and t-butyl methyl ether

Sources & evidence

ORD record
ord-4ccb2021bedd4238a8f2fd02eb866939
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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