Water → HCID 23085375, compound

HRID 2112881Notes

Reaction equation

HRID 2112881 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[NH:7][C:6]1=[O:16])[C:2]#[C:3][CH3:4].CI.[C:19](=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2[Cl:14])[N:7]([CH3:19])[C:6]1=[O:16])[C:2]#[C:3][CH3:4]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 23085394HCID 23085394, compound

Product 1

HCID 23085375HCID 23085375, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7-(2-Butynyl)-2,6-dichloro-7,9-dihydropurin-8-one (435 mg) was dissolved in N,N-dimethylformamide (10 mL), and then methyl iodide (158 μL) and anhydrous potassium carbonate (468 mg) were added to the solution. This reaction solution was stirred at room temperature for 12 hours, and then water (50 mL) was added. After stirring at room temperature for one hour, a white precipitate was collected by filtration. The white solid obtained was washed with water and t-butyl methyl ether to give the title compound (355 mg).

Workup

  1. stirringAfter stirring at room temperature for one hour
  2. filtrationa white precipitate was collected by filtration
  3. customThe white solid obtained
  4. washwas washed with water and t-butyl methyl ether

Sources & evidence

ORD record
ord-a4b9e2c4cd5b4da9ae170b9fcd0b68c0
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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