Water → HCID 86605133, compound

HRID 2112891Notes

Reaction equation

HRID 2112891 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[N:9][C:10]([Cl:15])=[N:11][C:12]=2Cl)[N:7]([CH3:16])[C:6]1=[O:17])[C:2]#[C:3][CH3:4].[C:18]([O:22][C:23](=[O:31])[NH:24][CH:25]1C[CH2:29][CH2:28][NH:27][CH2:26]1)([CH3:21])([CH3:20])[CH3:19].C([N:34](CC)CC)C.O>C(#N)C>[C:18]([O:22][C:23](=[O:31])[NH:24][CH:25]1[NH:34][CH2:29][CH2:28][N:27]([C:12]2[N:11]=[C:10]([Cl:15])[N:9]=[C:8]3[C:13]=2[N:5]([CH2:1][C:2]#[C:3][CH3:4])[C:6](=[O:17])[N:7]3[CH3:16])[CH2:26]1)([CH3:21])([CH3:20])[CH3:19]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 42330413-(Boc-amino)piperidine2×HCID 23085375HCID 23085375, compound2×

Product 1

HCID 86605133HCID 86605133, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

7-(2-Butynyl)-2,6-dichloro-9-methyl-7,9-dihydropurin-8-one (compound 1e) (100 mg) was dissolved in acetonitrile (1.5 mL). Piperidin-3-yl-carbamic acid t-butyl ester (compound 25b) (111 mg) and triethylamine (77 μL) were then added to this solution. After stirring the reaction solution at room temperature for 24 hours, water (6 mL) was added. After stirring this reaction solution at room temperature for 30 minutes, the precipitate was filtered, and the white solid obtained was washed with water and hexane to give the title compound (88 mg).

Workup

  1. stirringAfter stirring this reaction solution at room temperature for 30 minutes
  2. filtrationthe precipitate was filtered
  3. customthe white solid obtained
  4. washwas washed with water and hexane

Sources & evidence

ORD record
ord-b770d8ee24e74718863d2b31bcae6304
Source dataset
uspto-grants-2009_04
Patent number
US07524847B2

Reaction notes

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