Trifluoroacetic acid → HCID 86605134, compound

HRID 2112892Notes

Reaction equation

C(OC(=O)N[CH:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[N:22]=[C:21]([Cl:23])[N:20]=[C:19]3[C:15]=2[N:16]([CH2:26][C:27]#[C:28][CH3:29])[C:17](=[O:25])[N:18]3[CH3:24])[CH2:9]1)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[NH2:13][CH:12]1[CH2:32][CH2:8][CH2:9][N:10]([C:14]2[N:22]=[C:21]([Cl:23])[N:20]=[C:19]3[C:15]=2[N:16]([CH2:26][C:27]#[C:28][CH3:29])[C:17](=[O:25])[N:18]3[CH3:24])[CH2:11]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86605133HCID 86605133, compound

Product 1

HCID 86605134HCID 86605134, compound

Procedure

[1-[7-(2-Butynyl)-2-chloro-9-methyl-8-oxo-8,9-dihydro-7H-purin-6-yl]piperazin-3-yl]c arbamic acid t-butyl ester (15 mg) was dissolved in trifluoroacetic acid. This reaction solution was stirred at room temperature for five minutes, and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (7.23 mg).

Workup

concentrationconcentrated
customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record: ord-cac4d2c0d42a4369b5d0cc37546972c5
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524847B2

Reaction notes

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