Trifluoroacetic acid → HCID 68823841, compound

HRID 2112901Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]([CH2:32][C:33]#[C:34][CH3:35])[C:17](=[O:31])[N:18]3[C:23]2[CH:28]=[CH:27][C:26](=[O:29])[N:25]([CH3:30])[CH:24]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39].[CH2:32]([N:16]1[C:15]2[C:19](=[N:20][CH:21]=[N:22][C:14]=2[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:18]([C:23]2[CH:28]=[CH:27][C:26](=[O:29])[N:25]([CH3:30])[CH:24]=2)[C:17]1=[O:31])[C:33]#[C:34][CH3:35]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57642817HCID 57642817, compound

Product 1

HCID 68823841HCID 68823841, compound

Procedure

4-[7-(2-Butynyl)-9-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-8-oxo-8,9-dihydro-7H-purin-6-yl]piperazine-1-carboxylic acid t-butyl ester (15 mg) was dissolved in trifluoroacetic acid, and this reaction solution was stirred at room temperature for five minutes and then concentrated. The residue was purified by reverse phase high performance liquid chromatography to give the title compound (10.52 mg).

Workup

concentrationconcentrated
customThe residue was purified by reverse phase high performance liquid chromatography

Sources & evidence

ORD record: ord-1fea6fedbace4346b2039998d1322f73
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524847B2

Reaction notes

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