反应详情

Allyl amine (40 mL) was added to a solution of 4-ethoxy-3-nitropyridine hydrochloride [CAS No. 94602-04-7] (18.0 g) in ethanol (400 mL), and this was heated under reflux for eight hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The fraction eluted by ethyl acetate-hexane (1:1) gave the title compound (13.6 g).

1. temperatureunder reflux for eight hours
2. concentrationThe reaction solution was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography
4. washThe fraction eluted by ethyl acetate-hexane (1:1)