Methanol → HCID 68836863, compound

HRID 2112984Notes

Reaction equation

HRID 2112984 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]2[N:14]3[N:15]=[C:16]([NH2:18])[N:17]=[C:13]3[CH:12]=[C:11]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[CH:10]=2)[CH2:4][CH2:3]1.[S:25]([N:35]=[C:36]=[O:37])([C:28]1[CH:34]=[CH:33][C:31]([CH3:32])=[CH:30][CH:29]=1)(=[O:27])=[O:26].CO>CN(C=O)C>[S:25]([NH:35][C:36]([NH:18][C:16]1[N:17]=[C:13]2[CH:12]=[C:11]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[CH:10]=[C:9]([NH:8][CH:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[N:14]2[N:15]=1)=[O:37])([C:28]1[CH:29]=[CH:30][C:31]([CH3:32])=[CH:33][CH:34]=1)(=[O:26])=[O:27]

Participants

5

Reactant 3

HCID 887MethanolHCID 77703p-Toluenesulfonyl isocyanateHCID 131727431HCID 131727431, compound

Product 1

HCID 68836863HCID 68836863, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A suspension of the product of Step 1 (376 mg, 1.16 mmol) in DMF (4 mL) was treated with TosNCO (0.25 g, 1.3 mmol), then microwaved at 60° C. for 5 min. After stirring at room temperature for 18 h, MeOH (5 mL) was added and the resulting precipitate was collected by filtration and dried in vacuo to yield 1-tosyl-3-[5-(1-methyl-piperidin-4-ylamino)-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-urea.

Workup

  1. custommicrowaved at 60° C. for 5 min
  2. filtrationthe resulting precipitate was collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e66fdf1562b04c8b9237555203739d4e
Source dataset
uspto-grants-2009_04
Patent number
US07524860B2

Reaction notes

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