7-Aminoquinoline → N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

HRID 2113090Notes

Reaction equation

HRID 2113090 reaction equation

Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:19]=[C:18]2[C:13]([CH:14]=[CH:15][CH:16]=[N:17]2)=[CH:12][CH:11]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:9][C:10]2[CH:19]=[C:18]3[C:13]([CH:14]=[CH:15][CH:16]=[N:17]3)=[CH:12][CH:11]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 113777-Aminoquinoline

HCID 11430Potassium Carbonate

HCID 709434,6-Dichloropyrimidine

Product 1

HCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound could be prepared from 4,6-dichloro-pyrimidine and 7-aminoquinoline in the presence of K2CO3 and DMF.

Sources & evidence

ORD record: ord-1099f9af95e04c7194568bf753c83b1b
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07524874B2

Reaction notes

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