Dimethylformamide → [6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

HRID 2113092Notes

Reaction equation

HRID 2113092 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH3:25][N:26]([CH:28]=O)[CH3:27]>>[C:25]1([N:26]2[CH2:28][CH2:6][N:5]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:18]=[C:17]5[C:12]([CH:13]=[CH:14][CH:15]=[N:16]5)=[CH:11][CH:10]=4)[CH:3]=3)[CH2:4][CH2:27]2)[CH:17]=[CH:18][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

Product 1

HCID 22135548[6-(4-Phenyl-piperazin-1-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

Procedure

This compound could be prepared from (6-chloro-pyrimidin-4-yl)-quinolin-7-yl-amine and I-phenyl-piperazine in the presence of K2CO3 and DMF.

Sources & evidence

ORD record
ord-f426f598b15749e19035b94301ee6bb1
Source dataset
uspto-grants-2009_04
Patent number
US07524874B2

Reaction notes

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