Potassium Carbonate → HCID 68406876, compound

HRID 2113436Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:10][C:7]1[CH:8]=[CH:9][C:2]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 27745842-Fluoro-5-methylbenzonitrile

HCID 178418800HCID 178418800, compound

Product 1

HCID 68406876HCID 68406876, compound

Procedure

In analogy to example 5a, 2-fluoro-5-methyl-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 16 h at 90° C. After aqueous workup the title compound was obtained as a white solid (yield: 48%). MS: m/e=198.4 [M+H]+.

Sources & evidence

ORD record: ord-048c501b647b414bb21489163d0f40be
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07432256B2

Reaction notes

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