Potassium Carbonate → HCID 69106680, compound

HRID 2113463Notes

Reaction equation

HRID 2113463 reaction equation
F[C:2]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:10][C:9]1[C:2]([N:15]2[CH:16]=[C:12]([CH3:11])[N:13]=[CH:14]2)=[C:3]([CH:6]=[CH:7][CH:8]=1)[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 889352,3-DifluorobenzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 69106680HCID 69106680, compoundYield 28%

Procedure

In analogy to example 5a, 2,3-difluoro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 16 h at 90° C. After aqueous workup and crystallization from Ethyl acetate/diisopropylether the title compound was obtained as an off-white solid (yield: 28%). 1H-NMR (300 MHz, DMSO): δ=2.19 (d, J=0.9 Hz, 3H), 7.26 (s with fine splitting, 1H), 7.71-7.89 (m, 1H), 7.86-7.94 (m, 3H)

Workup

  1. customAfter aqueous workup and crystallization from Ethyl acetate/diisopropylether the title compound

Sources & evidence

ORD record
ord-e0fa76d2007d4885a0667230b37a07b3
Source dataset
uspto-grants-2008_10
Patent number
US07432256B2

Reaction notes

Loading…