Hydrochloric Acid → HCID 69200327, compound

HRID 2113481Notes

Reaction equation

HRID 2113481 reaction equation
[Cl:1][C:2]1[N:3]([CH2:33][C:34]#[C:35][CH3:36])[C:4]([C:11]([N:13]([CH2:22][C:23]2[CH:32]=[CH:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]=2)[NH:14]C(OC(C)(C)C)=O)=[O:12])=[C:5]([C:7]([O:9]C)=O)[N:6]=1.Cl>C(OCC)(=O)C.O1CCOCC1>[CH2:33]([N:3]1[C:4]2[C:11](=[O:12])[N:13]([CH2:22][C:23]3[CH:32]=[CH:31][C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[N:24]=3)[NH:14][C:7](=[O:9])[C:5]=2[N:6]=[C:2]1[Cl:1])[C:34]#[C:35][CH3:36]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69199505HCID 69199505, compound

Product 1

HCID 69200327HCID 69200327, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

2.80 g methyl 2-chloro-5-[N′-tert-butoxycarbonyl-N-(quinolin-2-ylmethyl)-hydrazinocarbonyl]-1-(but-2-ynyl)-1H-imidazol-4-carboxylate are dissolved in 50 ml of ethyl acetate. Then 1.5 ml of 4 M hydrochloric acid in dioxane are added, and the solution is stirred for 2 h at 50° C. Then the solution is cooled to ambient temperature, the precipitate formed is separated off, washed with ethyl acetate and diethyl ether and dried in the drying cupboard at 50° C.

Workup

  1. temperatureThen the solution is cooled to ambient temperature
  2. customthe precipitate formed
  3. customis separated off
  4. washwashed with ethyl acetate and diethyl ether
  5. customdried in the drying cupboard at 50° C.

Sources & evidence

ORD record
ord-99109724cfca4969a19c5fc4ffe3cc43
Source dataset
uspto-grants-2008_10
Patent number
US07432262B2

Reaction notes

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