Phosphorus oxychloride → 2-Chloro-4-(4-fluorophenyl)pyridine

HRID 2113545Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N+:11]([O-])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 187002504-(4-Fluoro-phenyl)-pyridine 1-oxide

Product 1

HCID 231207302-Chloro-4-(4-fluorophenyl)pyridine

Procedure

A mixture of 0.9 g (4.8 mmol) of 4-(4-fluorophenyl)pyridine-1-oxide and 10 mL of phosphoryl chloride is heated at reflux overnight.

Workup

temperatureis heated
temperatureat reflux overnight

Sources & evidence

ORD record: ord-921ad7bfd8214392960609e59c5cf2cb
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07432269B2

Reaction notes

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