Water → HCID 69291040, compound

HRID 2113878Notes

Reaction equation

HRID 2113878 reaction equation
[H-].[Na+].[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13]Cl)=[CH:9][CH:8]=1)[CH:4]=[CH2:5].[N:15]1[N:16]([CH2:20][CH2:21][OH:22])[N:17]=[CH:18][CH:19]=1.O>CN(C=O)C>[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][O:22][CH2:21][CH2:20][N:16]2[N:17]=[CH:18][CH:19]=[N:15]2)=[CH:9][CH:8]=1)[CH:4]=[CH2:5]

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 101031392H-1,2,3-Triazole-2-ethanolHCID 123479361-Allyloxy-4-chloromethyl-benzene

Product 1

HCID 69291040HCID 69291040, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

207 mg (8.21 mmol) 95% Sodium hydride were given at −50° C. to a solution of 1.00 g (5.47 mmol) 1-allyloxy-4-chloromethyl-benzene and 619 mg (5.47 mmol) 2-(2H-[1,2,3]-triazol-2-yl)-ethanol in 10.0 ml DMF. The mixture was allowed to warm slowly to r.t., stirred overnight and 6 ml water added. The formed oil was collected with 10 ml dichloromethane, the aqueous phase extracted with 10 ml dichloromethane and the combined organic phases dried over Na2SO4.

Workup

  1. customThe formed oil was collected with 10 ml dichloromethane
  2. extractionthe aqueous phase extracted with 10 ml dichloromethane
  3. dry with materialthe combined organic phases dried over Na2SO4

Sources & evidence

ORD record
ord-b046390b6b2f47d2af22c352ba58f69e
Source dataset
uspto-grants-2008_10
Patent number
US07432291B2

Reaction notes

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