Water → HCID 11168676, compound

HRID 2113882Notes

Reaction equation

HRID 2113882 reaction equation
[H-].[Na+].[N:3]1([CH2:8][CH2:9][O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH:7]=[CH:6][N:5]=[N:4]1.Cl[CH2:20][C:21]1[N:22]=[C:23]([CH:26]=[CH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][CH:29]=2)[S:24][CH:25]=1.O>CN(C=O)C>[F:38][C:35]([F:36])([F:37])[O:34][C:31]1[CH:32]=[CH:33][C:28](/[CH:27]=[CH:26]/[C:23]2[S:24][CH:25]=[C:21]([CH2:20][O:18][C:15]3[CH:14]=[CH:13][C:12]([CH2:11][O:10][CH2:9][CH2:8][N:3]4[CH:7]=[CH:6][N:5]=[N:4]4)=[CH:17][CH:16]=3)[N:22]=2)=[CH:29][CH:30]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 210758954-(2-[1,2,3]Triazol-1-yl-ethoxymethyl)-phenolHCID 69291036HCID 69291036, compound

Product 1

HCID 11168676HCID 11168676, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

182 mg (7.00 mmol) 95% Sodium hydride were given to a solution of 1.50 g (7.00 mmol) 4-(2-[1,2,3]triazol-1-yl-ethoxymethyl)-phenol in 7.0 ml DMF and stirred for 15 min. 2.06 g (7.00 mmol) 4-Chloromethyl-2-[2-(4-trifluoromethoxy-phenyl)-vinyl]-thiazole were added and stirring continued at r.t. overnight. After addition of 20 ml water the resulting precipitate was washed twice with 10 ml water, then with n-heptane and finally a little amount of diethyl ether and dried at 45° C. in vacuum. Yield 2.4 g.

Workup

  1. stirringstirring
  2. waitcontinued at r.t. overnight
  3. washwas washed twice with 10 ml water
  4. dry with materialwith n-heptane and finally a little amount of diethyl ether and dried at 45° C. in vacuum

Sources & evidence

ORD record
ord-763c25e9499941a1bc9be08caa448b4b
Source dataset
uspto-grants-2008_10
Patent number
US07432291B2

Reaction notes

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