反应详情

4-Dimethylaminopyridine (55 mg), 3-(2,2′-bisethylcarbamoyl-2-phenylethoxy)propionic acid (115 mg) and 4′-trifluoromethylbiphenyl-2-carboxylic acid (2-dimethylcarbamoyl-4-hydroxyphenyl)amide (161 mg) were dissolved in acetone (5 mL), and thereto was added WSC (86 mg). The mixture was stirred at room temperature for 3 hours and then concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=4:1→1:0) to give 3-(2,2′-bisethylcarbamoyl-2-phenylethoxy)propionic acid 3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl ester (150 mg).

1. concentrationconcentrated
2. customThe residue was purified by column chromatography on silica gel (ethyl acetate:hexane=4:1→1:0)