HCID 58786867, compound → HCID 21098182, compound

HRID 2114805Notes

Reaction equation

HRID 2114805 reaction equation
[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][N:19]2C(OCC2C=CC=CC=2)=O)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:29])([CH3:30])[CH3:28])=[O:25])[CH2:21][CH2:20][NH:19]2)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58786867HCID 58786867, compound

Product 1

HCID 21098182HCID 21098182, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

1-Benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-2-methylpiperazine-1,4-dicarboxylate was dissolved in AcOEt (20 ml/mmol) and hydrogenated at atm pressure on 10% (w/w) Pd/C over night. After filtration of the catalyst, solvent was evaporated to give crude product.

Workup

  1. filtrationAfter filtration of the catalyst, solvent
  2. customwas evaporated
  3. customto give crude product

Sources & evidence

ORD record
ord-98190c1ec88e4180be407c3998f2b7e7
Source dataset
uspto-grants-2008_10
Patent number
US07435734B2

Reaction notes

Loading…