4-Aminobenzonitrile → N-(4-Cyanophenyl)-α-oxo-4-(phenylmethyl)-1-piperidineacetamide

HRID 2114965Notes

Reaction equation

HRID 2114965 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH2:10]([CH:17]1[CH2:22][CH2:21][N:20]([C:23](=[O:27])[C:24](O)=[O:25])[CH2:19][CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(OCC)C>[CH2:10]([CH:17]1[CH2:18][CH2:19][N:20]([C:23](=[O:27])[C:24]([NH:1][C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)=[O:25])[CH2:21][CH2:22]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 133964-AminobenzonitrileHCID 16110264(4-Benzylpiperidin-1-yl)oxoacetic acid

Product 1

HCID 69100690N-(4-Cyanophenyl)-α-oxo-4-(phenylmethyl)-1-piperidineacetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 4-amino-benzonitrile (Aldrich) and (4-benzyl-piperidin-1-yl)-oxo-acetic acid according to the method described in Example 2. Melting Point: 166-169° C. (diethylether)

Sources & evidence

ORD record
ord-18171380dadf4ca5ac780b4655988f4e
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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