Hydrochloric Acid → HCID 69100507, compound

HRID 2115029Notes

Reaction equation

HRID 2115029 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:27])[C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=2)=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>C(OCC)(=O)C>[ClH:28].[NH2:24][C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:15](=[O:16])[C:14]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]2)=[O:27])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 16804368HCID 16804368, compound

Product 1

HCID 69100507HCID 69100507, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound is prepared from 2-(4-benzyl-piperidin-1-yl)-N-(4-nitrophenyl)-2-oxo-acetamide (Example 70) according to the method described in Example 11. The residue is treated with 2.5 N hydrochloric acid in ethyl acetate to yield the title compound. Melting Point: >260° C. (ethyl acetate)

Sources & evidence

ORD record
ord-987d3e3d67fd4477b930cc4d87a699fd
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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