Hydrochloric Acid → HCID 69100557, compound

HRID 2115030Notes

Reaction equation

HRID 2115030 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9](=[O:35])[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:34])[C:19]([N:21]2[CH2:26][CH2:25][CH:24]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:23][CH2:22]2)=[O:20])[CH:12]=1)(C)(C)C.[ClH:37]>C(OCC)(=O)C>[ClH:37].[NH2:7][CH2:8][C:9]([NH:10][C:11]1[CH:12]=[C:13]([NH:17][C:18](=[O:34])[C:19]([N:21]2[CH2:22][CH2:23][CH:24]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:25][CH2:26]2)=[O:20])[CH:14]=[CH:15][CH:16]=1)=[O:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69099965HCID 69099965, compound

Product 1

HCID 69100557HCID 69100557, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 0.5 g (1 mmol) of ({3-[2-(4-benzyl-piperidin-1-yl)-2-oxo-acetyl-amino]-phenylcarbamoyl}-methyl)-carbamic acid tert-butyl ester (Example 69) and 20 ml of 2.5 N hydrochloric acid in ethyl acetate is stirred at room temperature for 1 hour. The precipitated product is filtered off and washed with ethyl acetate to yield 0.41 g (95.1%) of the title compound. Melting Point: 85-90° C. (ethyl acetate)

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-afc7734494ab44a4bd0162eb5ca60272
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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