Diisopropyl Ether → HCID 69100254, compound

HRID 2115052Notes

Reaction equation

Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:26])[C:11]([N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)=[O:12])=[CH:5][CH:4]=1.[C:27]([O:31][C:32](NCC(O)=O)=[O:33])([CH3:30])([CH3:29])[CH3:28].C(OC(C)C)(C)C>>[C:27]([O:31][C:32](=[O:33])[NH:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:26])[C:11]([N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:15][CH2:14]2)=[O:12])=[CH:5][CH:4]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

Reactant 3

HCID 7914Diisopropyl Ether

HCID 78288N-(tert-butoxycarbonyl)glycine

HCID 69100507HCID 69100507, compound

Product 1

HCID 69100254HCID 69100254, compound

Procedure

The title compound is prepared from N-(4-amino-phenyl)-2-(4-benzyl-piperidin-1-yl)-2-oxo-acetamide hydrochloride (Example 73) and N-(tert-butoxycarbonyl)-glycine (Aldrich) according to the method described in Example 94. Melting Point: 177-179° C. (diisopropylether)

Sources & evidence

ORD record: ord-f3518491d1ab4b208b6d548ae387fdb4
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435744B2

Reaction notes

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