Diisopropyl Ether → 2-[4-[4-Methoxy-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

HRID 2115061Notes

Reaction equation

HRID 2115061 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)=[CH:10][C:4]=2[O:3]1.[CH3:17][O:18][C:19]1[CH:31]=[CH:30][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:20]=1.C(OC(C)C)(C)C>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]2[CH2:25][CH2:26][N:27]([C:13](=[O:15])[C:12]([NH:11][C:9]3[CH:8]=[CH:7][C:5]4[NH:6][C:2](=[O:1])[O:3][C:4]=4[CH:10]=3)=[O:16])[CH2:28][CH2:29]2)=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 7914Diisopropyl EtherHCID 37327404-((4-Methoxyphenyl)methyl)piperidineHCID 53306576N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid

Product 1

HCID 102232122-[4-[4-Methoxy-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid (Example 43e) and 4-(4-methoxy-benzyl)-piperidine according to the method described in Example 1c. Melting Point: 193-197° C. (diisopropylether)

Sources & evidence

ORD record
ord-cb1e682102264ce19eee7237ded5d3c4
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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