Diisopropyl Ether → 2-[4-[3-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

HRID 2115065Notes

Reaction equation

HRID 2115065 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)=[CH:10][C:4]=2[O:3]1.[CH3:17][C:18]1[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=1)[CH2:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.C(OC(C)C)(C)C>>[CH3:17][C:18]1[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=1)[CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([C:13](=[O:15])[C:12]([NH:11][C:9]2[CH:8]=[CH:7][C:5]3[NH:6][C:2](=[O:1])[O:3][C:4]=3[CH:10]=2)=[O:16])[CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 7914Diisopropyl EtherHCID 111597934-(3-Methyl-benzyl)-piperidineHCID 53306576N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid

Product 1

HCID 102005842-[4-[3-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid (Example 43e) and 4-(3-methyl-benzyl)-piperidine according to the method described in Example 2. Melting Point: 204-208° C. (diisopropylether)

Sources & evidence

ORD record
ord-a87dcc3ab28f429989ba451c543f0663
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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