Benzaldehyde → 4-[(4-Fluorophenyl)methyl]-N-[3-[(phenylmethyl)amino]phenyl]-1-piperidineacetamide

HRID 2115113Notes

Reaction equation

HRID 2115113 reaction equation
Cl.Cl.[NH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:27])[CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)[CH:7]=[CH:8][CH:9]=1.[CH:28](=O)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>C(OCC)C.CCCCCC>[CH2:28]([NH:3][C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:27])[CH2:12][N:13]2[CH2:14][CH2:15][CH:16]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[CH2:17][CH2:18]2)[CH:7]=[CH:8][CH:9]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 69100145HCID 69100145, compound

Product 1

HCID 691004844-[(4-Fluorophenyl)methyl]-N-[3-[(phenylmethyl)amino]phenyl]-1-piperidineacetamide

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

The title compound is prepared from N-(3-amino-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamid dihydrochloride (Example 183) and benzaldehyde according to the method described in Example 177. Melting Point: 98-100° C. (diethylether-hexane)

Sources & evidence

ORD record
ord-f9e414d369634b539b2dee4fc632a0f0
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

Loading…