Hydrochloric Acid → HCID 69100369, compound

HRID 2115117Notes

Reaction equation

HRID 2115117 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]([NH:16][C:17]3[CH:26]=[CH:25][C:20]4[NH:21][C:22](=[O:24])[O:23][C:19]=4[CH:18]=3)=[O:15])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[ClH:29]>C(OCC)C.C(OCC)(=O)C>[ClH:29].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]([NH:16][C:17]3[CH:26]=[CH:25][C:20]4[NH:21][C:22](=[O:24])[O:23][C:19]=4[CH:18]=3)=[O:15])[CH2:11][CH2:12]2)=[CH:27][CH:28]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10221566HCID 10221566, compound

Product 1

HCID 69100369HCID 69100369, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred suspension of 1,5 g (3.9 mmol) of 2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-N-(2-oxo-2,3-dihydro-1H-benzoxazol-6-yl)-acetamide (Example 142b) in 40 ml of diethylether is added 4 ml of 2.5 N hydrochloric acid in ethyl acetate. The mixture is stirred for 1 h at room temperature, the crystals are filtered off and washed with diethylether to yield 1.64 g (100%) of the title compound. Melting Point: 210-216° C. (dec.) (diethylether)

Workup

  1. filtrationthe crystals are filtered off
  2. washwashed with diethylether

Sources & evidence

ORD record
ord-5913c9421bdf4e1aac90e1ee61a32e4b
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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