反应详情

4-(4-propylcyclohexyl)phenylboronic acid (1.3 g), 6-bromo-3,4-dihydrocoumarin (1.0 g), potassium carbonate (1.2 g), tetrakistriphenylphosphine-palladium (51 mg), and tetrabutylammonium bromide (10 mg) were suspended in DME (10 ml), and the suspension was stirred under reflux by heating for 3 hours. After completion of the reaction, the reaction mixture was added in ice water and extracted with toluene. An organic layer was washed with water and then dried over anhydrous magnesium sulfate. The solution was concentrated in vacuo and then subjected to isolation and purification by silica gel column chromatography, thereby obtaining a titled compound (500 mg). As a result of a variety of instrumental analyses, it was confirmed that this was the titled compound.

1. temperatureunder reflux
2. temperatureby heating for 3 hours
3. customAfter completion of the reaction
4. extractionextracted with toluene
5. washAn organic layer was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationThe solution was concentrated in vacuo
8. customsubjected to isolation and purification by silica gel column chromatography