反应详情

Clarithromycin (J. Antibiot. 43 (1990) 544-549) (1.00 g, 1.34 mmol) and SnCl2 2H2O (0.307 g, 1.36 mmol) were dissolved in DMF (10 mL) and stirred at RT for 1 hour. A solution of diazomethane in diethylether prepared by Method B (cca 6 mmol) was added and the resulting mixture was stirred at RT for 4 hours. The mixture was diluted with aq. NaHCO3 (50 mL) and extracted with ethyl-acetate (3×30 mL). The organic layer was dried over Na2SO4, and concentrated to afford a mixture of the title and starting compounds (24%:73% LC-MS).

1. stirringthe resulting mixture was stirred at RT for 4 hours
2. extractionextracted with ethyl-acetate (3×30 mL)
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated
5. customto afford
6. additiona mixture of the title