HCID 46218137, compound → HCID 72569092, compound
Reaction equation
[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:3][CH2:4][CH:5]1[C:8](=[O:9])[N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])=[CH:12][CH:11]=2)[CH:6]1[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1.[CH:38]1[CH:43]=[C:42]2[CH:44]([CH2:51][O:52][C:53]([NH:55][C@H:56]([C:67](O)=[O:68])[CH2:57][C:58]3[CH:63]=[CH:62][C:61]([N:64]=[N+:65]=[N-:66])=[CH:60][CH:59]=3)=[O:54])[C:45]3[C:50]([C:41]2=[CH:40][CH:39]=1)=[CH:49][CH:48]=[CH:47][CH:46]=3.C1C2C(COC(=O)N(CCCCC(=O)NC3C=CC(N4C(=O)C(CCC(O)C5C=CC=CC=5)C4C4C=CC(OC)=CC=4)=CC=3)C3C=CC=CC=3)C3C(=CC=CC=3)C=2C=CC=1>CN(C)C=O>[CH:43]1[C:42]2[CH:44]([CH2:51][O:52][C:53](=[O:54])[NH:55][CH:56]([C:67](=[O:68])[NH:22][CH2:21][CH2:20][CH2:19][CH2:18][C:17](=[O:23])[NH:16][C:13]3[CH:12]=[CH:11][C:10]([N:7]4[C:8](=[O:9])[CH:5]([CH2:4][CH2:3][CH:2]([OH:1])[C:32]5[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=5)[CH:6]4[C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=4)=[CH:15][CH:14]=3)[CH2:57][C:58]3[CH:59]=[CH:60][C:61]([N:64]=[N+:65]=[N-:66])=[CH:62][CH:63]=3)[C:45]3[C:50](=[CH:49][CH:48]=[CH:47][CH:46]=3)[C:41]=2[CH:40]=[CH:39][CH:38]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
200 mg (0.40 mmol) of product 9 and 340 mg (0.79 mmol) of Fmoc -p-azido-Phe-OH 10 (Bachem) are solved in 4 ml DMF (dimethylformamide) and reacted according to production of product 8. 300 mg (82%) of product 11 is obtained in form of an amorphic solid compound: C54H53N7O7 (912.07) MS (ESI+) 912.5 (M+H+).
Workup
- customreacted
Sources & evidence
- ORD record
- ord-1ba2fa475b0c49ccb765ffa77e34b380
- Source dataset
- uspto-grants-2008_10
- Patent number
- US07435727B2
Reaction notes
Loading…