Diethylamine → HCID 72569089, compound

HRID 2115192Notes

Reaction equation

HRID 2115192 reaction equation
C1C2C(COC(=O)[NH:17][CH:18]([C:29](=[O:67])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35](=[O:66])[NH:36][C:37]3[CH:42]=[CH:41][C:40]([N:43]4[C:46](=[O:47])[CH:45]([CH2:48][CH2:49][CH:50]([OH:57])[C:51]5[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=5)[CH:44]4[C:58]4[CH:63]=[CH:62][C:61]([O:64][CH3:65])=[CH:60][CH:59]=4)=[CH:39][CH:38]=3)[CH2:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]=[N+:27]=[N-:28])=[CH:22][CH:21]=3)C3C(=CC=CC=3)C=2C=CC=1.C(NCC)C.OC(C1C=CC=CC=1)CCC1C(=O)N(C2C=CC(NC(=O)CCCCN)=CC=2)C1C1C=CC(OC)=CC=1>CN(C)C=O>[OH:57][CH:50]([C:51]1[CH:52]=[CH:53][CH:54]=[CH:55][CH:56]=1)[CH2:49][CH2:48][CH:45]1[C:46](=[O:47])[N:43]([C:40]2[CH:39]=[CH:38][C:37]([NH:36][C:35](=[O:66])[CH2:34][CH2:33][CH2:32][CH2:31][NH:30][C:29](=[O:67])[CH:18]([NH2:17])[CH2:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]=[N+:27]=[N-:28])=[CH:22][CH:21]=3)=[CH:42][CH:41]=2)[CH:44]1[C:58]1[CH:59]=[CH:60][C:61]([O:64][CH3:65])=[CH:62][CH:63]=1

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 68639007HCID 68639007, compoundHCID 72569092HCID 72569092, compound

Product 1

HCID 72569089HCID 72569089, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

300 mg (0.33 mmol) of product 11 and 0.8 ml of diethylamine are solved in 4 ml DMF (dimethylformamide) and reacted according to production of compound 9. 42 mg (19%) of compound 12 is obtained in form of an amorphic solid compound: C39H43N7O5 (689.82) MS (ESI+) 690.3 (M+H+)

Workup

  1. customreacted

Sources & evidence

ORD record
ord-bd3becef37494888b557a65dd5463b88
Source dataset
uspto-grants-2008_10
Patent number
US07435727B2

Reaction notes

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