2-Chlorobenzaldehyde → HCID 11281991, compound

HRID 2115200Notes

Reaction equation

HRID 2115200 reaction equation
CO[C:3]1[CH:4]=[C:5]([C:9]([C:18]2[CH:22]=[CH:21][S:20][CH:19]=2)=[C:10]2[CH2:16][CH:15]3[NH:17][CH:12]([CH2:13][CH2:14]3)[CH2:11]2)[CH:6]=[CH:7][CH:8]=1.[Cl:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH:26]=O.CC1C=CC=CC=1[CH:35]=[O:36]>>[Cl:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][N:17]1[CH:12]2[CH2:13][CH2:14][CH:15]1[CH2:16][C:10](=[C:9]([C:5]1[CH:4]=[CH:3][C:8]([O:36][CH3:35])=[CH:7][CH:6]=1)[C:18]1[CH:22]=[CH:21][S:20][CH:19]=1)[CH2:11]2

Participants

4

Reactant 3

HCID 69962-ChlorobenzaldehydeHCID 107222-MethylbenzaldehydeHCID 11266931HCID 11266931, compound

Product 1

HCID 11281991HCID 11281991, compound

Procedure

Following the protocol for Example 15, and substituting 3-[(4-methoxy-phenyl)-thiophen-3-yl-methylene]-8-aza-bicyclo[3.2.1]octane for 3-[(3-methoxy-phenyl)-thiophen-3-yl-methylene]-8-aza-bicyclo[3.2.1]octane and 2-chlorobenzaldehyde for 2-methylbenzaldehyde the title compound was obtained; MS m/z (MH+) 437; 1H NMR 300 MHz (MeOD-d4) δ 6.80-7.67 (m, 11H), 3.76 (s, 3H), 3.71 (s, 2H), 3.21-3.30 (m, 2H), 2.01-2.48 (m, 6H), 1.61-1.68 (m, 2H).

Sources & evidence

ORD record
ord-156c8ffa6807400da6ba20ec665e79ea
Source dataset
uspto-grants-2008_10
Patent number
US07435822B2

Reaction notes

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