Diethylamine → HCID 58978445, compound

HRID 2115556Notes

Reaction equation

HRID 2115556 reaction equation
C1C2C(=CC=C(S(N(CC(O)=O)C3C=CC(C)=CC=3)(=O)=O)C=2)CCN1.C(NCC)C.[CH2:31]([N:33]([CH2:60][CH3:61])[C:34](=[O:59])[CH2:35][N:36]([S:44]([C:47]1[CH:56]=[C:55]2[C:50]([CH2:51][CH2:52][N:53](C=O)[CH2:54]2)=[CH:49][CH:48]=1)(=[O:46])=[O:45])[C:37]1[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=1)[CH3:32]>C(O)=O>[CH2:60]([N:33]([CH2:31][CH3:32])[C:34](=[O:59])[CH2:35][N:36]([S:44]([C:47]1[CH:56]=[C:55]2[C:50]([CH2:51][CH2:52][NH:53][CH2:54]2)=[CH:49][CH:48]=1)(=[O:46])=[O:45])[C:37]1[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=1)[CH3:61]

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 66885820N-(4-Methylphenyl)-N-[(1,2,3,4-tetrahydro-7-isoquinolinyl)sulfonyl]glycineHCID 86615720HCID 86615720, compound

Product 1

HCID 58978445HCID 58978445, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

prepared by reaction of [(1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl)-p-tolyl-amino]-acetic acid with diethylamine; due to the presence of formic acid in the eluent of the HPLC chromatography the product contained considerable amounts of N,N-diethyl-2-[(2-formyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl)-p-tolyl-amino]-acetamide (LC-MS: rt=0.91 min, 444 (M+1, ES+))

Sources & evidence

ORD record
ord-3083c4eb2ace494ca2579974fd4cc55f
Source dataset
uspto-grants-2008_10
Patent number
US07435815B2

Reaction notes

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