反应详情

A solution of the product of Example 8B (1.57 g, 14.05 mmoles), imidazole (1.43 g, 21.08 mmoles), and Tert-butyl-chlorodiphenylsilane (4.76 gm, 17.4 mmoles) in N,N-dimethylformamide (10 mL) was stirred for five hours at 23° C. The reaction was partitioned between ethyl acetate and water. The organic layer was washed with brine (25 mL), dried with MgSO4, filtered, and solvent evaporated in vacuo. The crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10) to provide the title compound as an oil.

1. customThe reaction was partitioned between ethyl acetate and water
2. washThe organic layer was washed with brine (25 mL)
3. dry with materialdried with MgSO4
4. filtrationfiltered
5. customsolvent evaporated in vacuo
6. customThe crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10)