Benzyl chloroformate → HCID 69108396, compound

HRID 2116087Notes

Reaction equation

HRID 2116087 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]1[CH2:8][C:7]2[CH:9]=[CH:10][CH:11]=[C:12]([C:13]3[C:18]([Cl:19])=[CH:17][C:16]([Cl:20])=[CH:15][C:14]=3[Cl:21])[C:6]=2[O:5]1.C(N(C(C)C)CC)(C)C.Cl[C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33]>>[CH3:1][N:2]([CH2:3][CH:4]1[CH2:8][C:7]2[CH:9]=[CH:10][CH:11]=[C:12]([C:13]3[C:14]([Cl:21])=[CH:15][C:16]([Cl:20])=[CH:17][C:18]=3[Cl:19])[C:6]=2[O:5]1)[C:32](=[O:33])[O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 3

HCID 10387Benzyl chloroformateHCID 81531DiisopropylethylamineHCID 68966435HCID 68966435, compound

Product 1

HCID 69108396HCID 69108396, compoundYield 99%

Procedure

Treatment of (±)-N-methyl-1-[7-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine (1.1 g, 3.57 mmol) with diisopropylethylamine (0.69 g, 5.35 mmol) and benzyl chloroformate (0.0.82 g, 4.28 mmol) generally according to the procedure described for Intermediate 12 provided 1.6 g (99%) of (±)-benzyl methyl{[7-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}carbamate as a colorless oil.

Sources & evidence

ORD record
ord-d28a035dc62341d29072ac27e0b06b9f
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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