Methylamine → HCID 69107769, compound

HRID 2116311Notes

Reaction equation

HRID 2116311 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[CH:19][CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=4[F:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[CH3:30][NH:31][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=3[F:29])[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599144HCID 86599144, compound

Product 1

HCID 69107769HCID 69107769, compound

Procedure

The title compound was prepared (0.137 g, 68%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2,4-difluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.366 g, 0.88 mmol) and methylamine (0.273 g, 8.80 mmol). mp 156-160° C.

Sources & evidence

ORD record
ord-26a62cb98baa4f6a908ad4cf5bd25725
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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