Methylamine → HCID 15941774, compound

HRID 2116312Notes

Reaction equation

HRID 2116312 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[CH:19][CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=4[Cl:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[CH3:30][NH:31][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=3[Cl:29])[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599103HCID 86599103, compound

Product 1

HCID 15941774HCID 15941774, compound

Procedure

The title compound was prepared (0.137 g, 47%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2,4-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.125 g, 0.278 mmol) and methylamine (0.086 g, 2.78 mmol). mp 190-192° C.

Sources & evidence

ORD record
ord-8cc210b24f6e4a45a17c0565b4f6c7f9
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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