Methylamine → HCID 69108692, compound

HRID 2116317Notes

Reaction equation

HRID 2116317 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[CH:19][CH:20]=[C:21]([C:22]4[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=4[O:29][CH3:30])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:31][NH2:32]>>[CH3:31][NH:32][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=3[O:29][CH3:30])[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599154HCID 86599154, compound

Product 1

HCID 69108692HCID 69108692, compound

Procedure

The title compound was prepared (0.058 g, 79%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(5-chloro-2-methoxyphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.095 g, 0.213 mmol) and methylamine (0.045 g, 2.1 mmol). mp 201-203° C.

Sources & evidence

ORD record
ord-6e4b0fb4c014427fa076eb2ac91bfbc0
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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