Potassium Carbonate → HCID 59814865, compound

HRID 2116658Notes

Reaction equation

HRID 2116658 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]([C:9]1[S:13][C:12]([SH:14])=[N:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].Br[C:18]1[C:27]([CH3:28])=[C:26]2[C:21]([C:22]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)=[CH:23][C:24](=[O:29])[O:25]2)=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[F:36][C:33]1[CH:32]=[CH:31][C:30]([C:22]2[C:21]3[C:26](=[C:27]([CH3:28])[C:18]([S:14][C:12]4[S:13][C:9]([C:3]([OH:8])([C:4]([F:7])([F:6])[F:5])[C:2]([F:15])([F:1])[F:16])=[CH:10][N:11]=4)=[CH:19][CH:20]=3)[O:25][C:24](=[O:29])[CH:23]=2)=[CH:35][CH:34]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 59814839HCID 59814839, compoundHCID 178519848HCID 178519848, compound

Product 1

HCID 59814865HCID 59814865, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Employing the procedure of Example 1, Step 3 using 1,1,1,3,3,3-hexafluoro-2-(2-mercapto-1,3-thiazol-5-yl)propan-2-ol, (0.332 g, 1.2 mmol), 7-bromo-4-(4-fluorophenyl)-8-methyl-2H-chromen-2-one (0.430 g, 1.3 mmol) and potassium carbonate (0.404 g, 2.9 mmol) in NMP, the title compound was obtained. 1H NMR (400 MHz, acetone-d6): δ 8.21 (s, 1H, OH), 7.97 (s, 1H), 7.36-7.72 (m, 6H), 6.50 (s, 1H), 2.67 (s, 3H).

Sources & evidence

ORD record
ord-a90ca8fec5d94212a758d5cb5f7bca84
Source dataset
uspto-grants-2008_10
Patent number
US07439260B2

Reaction notes

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