Lauric Acid → 2,6-dimethyl-7a-undecyl-tetrahydro-2H-oxazolo[2,3-b]oxazole

HRID 2116740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2116740
[CH3:1][CH:2]([OH:9])[CH2:3][NH:4][CH2:5][CH:6]([OH:8])[CH3:7].[C:10](O)(=O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O>[CH3:1][CH:2]1[O:9][C:21]2([CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH3:10])[O:8][CH:6]([CH3:7])[CH2:5][N:4]2[CH2:3]1

Komponenten

4

Edukt 2

HCID 3893Lauric AcidHCID 8086Diisopropanolamine3×

Produkt 1

HCID 692034952,6-dimethyl-7a-undecyl-tetrahydro-2H-oxazolo[2,3-b]oxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
186 °C

Versuchsvorschrift

To a 1 liter stirred reactor, equipped with a distillation column, condenser, and graduated receiver, the following constituents were added: 166.5 g of diisopropanol amine (DIPA) and 200.0 9 (98%) of lauric acid. The contents were heated to 186° C. under a nitrogen blanket. After 111 minutes, 15 ml of water had come overhead. The batch temperature was allowed to drop to 172° C. while the pressure was dropped to 10,531 Pa. The batch temperature was then raised to 195° C. and the pressure was raised to 13,330 Pa. The batch temperature was slowly raised to 220° C. while the batch pressure was increased to 19,800 Pa. An additional 13 ml of a mixture of water and DIPA came overhead. The temperature was then allowed to drop to 182° C. while the pressure was dropped to 280 Pa. During the pressure reduction, 31.2 g of DIPA came overhead. As the pressure was dropped to 227 Pa and the temperature increased to 221° C., a total of 93.4 g of the amide acetal of lauric acid was collected.

Aufarbeitung

  1. customequipped with a distillation column, condenser
  2. additionthe following constituents were added
  3. customto drop to 172° C. while the pressure
  4. additionwas dropped to 10,531 Pa
  5. temperatureThe batch temperature was then raised to 195° C.
  6. temperaturethe pressure was raised to 13,330 Pa
  7. temperatureThe batch temperature was slowly raised to 220° C. while the batch pressure
  8. temperaturewas increased to 19,800 Pa
  9. customto drop to 182° C. while the pressure
  10. additionwas dropped to 280 Pa
  11. additionAs the pressure was dropped to 227 Pa
  12. temperaturethe temperature increased to 221° C.
  13. customa total of 93.4 g of the amide acetal of lauric acid was collected

Quellen und Nachweise

ORD-Eintrag
ord-9b0e9ec8a88f40ed8d4ae087a944b79d
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07439354B2

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