Hydroxyamine hydrochloride → HCID 86609838, compound

HRID 2116840Notes

Reaction equation

HRID 2116840 reaction equation
[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=O)[CH2:14][O:15][C:16]2[CH:27]=[CH:26][C:19]([C:20]([O:22]CC=C)=[O:21])=[C:18]([OH:28])[CH:17]=2)=[CH:9][C:8]=1[C:30]([CH3:33])([CH3:32])[CH3:31])(=[O:3])[CH3:2].Cl.[NH2:35][OH:36]>N1C=CC=CC=1>[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[N:35][OH:36])[CH2:14][O:15][C:16]2[CH:27]=[CH:26][C:19]([C:20]([OH:22])=[O:21])=[C:18]([OH:28])[CH:17]=2)=[CH:9][C:8]=1[C:30]([CH3:33])([CH3:32])[CH3:31])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 69290738HCID 69290738, compound

Product 1

HCID 86609838HCID 86609838, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a manner similar to that of Example 1.g, by reaction of 370 mg (0.8 mmol) of allyl 4-{2-[4-(acetylethylamino)-3-tert-butylphenyl]-2-oxoethoxy}-2-hydroxybenzoate with 284 mg (4 mmol) of hydroxylamine hydrochloride and 320 μl of pyridine. A yellowish paste is obtained (m=380 mg, yield=99%).

Workup

  1. customA yellowish paste is obtained (m=380 mg, yield=99%)

Sources & evidence

ORD record
ord-418f55cce90c416787f3d455064b7436
Source dataset
uspto-grants-2008_10
Patent number
US07439396B2

Reaction notes

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