HCID 58625829, compound → HCID 178456369, compound

HRID 2116902Notes

Reaction equation

HRID 2116902 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[N:13]=[C:14]([N:35]3[CH2:40][CH2:39][N:38]([C:41]4[C:46]([C:47]([F:50])([F:49])[F:48])=[CH:45][CH:44]=[CH:43][N:42]=4)[CH2:37][CH2:36]3)[N:15](COCC[Si](C)(C)C)[C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>C(O)(C(F)(F)F)=O>[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]([C:12]2[N:13]=[C:14]([N:35]3[CH2:36][CH2:37][N:38]([C:41]4[C:46]([C:47]([F:48])([F:50])[F:49])=[CH:45][CH:44]=[CH:43][N:42]=4)[CH2:39][CH2:40]3)[NH:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)=[O:11])[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 58625829HCID 58625829, compound

Product 1

HCID 178456369HCID 178456369, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of (4-isopropylpiperazin-1-yl)(5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)methanone from step (f) above was dissolved in TFA (1 mL). The solution was stirred at RT for 1 h. The solvent was removed and the residue was purified on silica gel using ISCO Combiflash® system with DCM/2M methanolic ammonia gradient to give the title compound as a white solid. MS (ESI, positive ion) m/z: 596 (M+1).

Workup

  1. customThe solvent was removed
  2. customthe residue was purified on silica gel using ISCO Combiflash® system with DCM/2M methanolic ammonia gradient

Sources & evidence

ORD record
ord-3e03668f073849a8a20bb34b5a5db14a
Source dataset
uspto-grants-2008_10
Patent number
US07439360B2

Reaction notes

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