Hydrochloric Acid → HCID 178429613, compound

HRID 2117109Notes

Reaction equation

HRID 2117109 reaction equation
[OH:1][C:2]1[C:7]2=[C:8]([CH3:16])[C:9]([C:11]([O:13]CC)=[O:12])=[CH:10][N:6]2[N:5]=[CH:4][N:3]=1.[OH-].[Na+].Cl>C1COCC1>[OH:1][C:2]1[C:7]2=[C:8]([CH3:16])[C:9]([C:11]([OH:13])=[O:12])=[CH:10][N:6]2[N:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469453HCID 178469453, compound

Product 1

HCID 178429613HCID 178429613, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of ethyl 4-hydroxy-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (442 mg, 2.0 mmol) (see example 6 of US Pat. App. 2003/0186982, the disclosure of which is herein incorporated by reference ) in 10 mL of THF was added a solution of NaOH (1 N, 6.0 mL). The mixture was heated at 60° C. overnight and HPLC analysis indicated the completion of the reaction. After cooling down, the solution was neutralized with 6.0 mL of 1 N HCl. The organic solvent was then removed and the solid was collected after filtration to the title compound (350 mg, 91%). MS(ESI+) m/z 194.2 (M+H)+.

Workup

  1. customthe completion of the reaction
  2. temperatureAfter cooling down
  3. customThe organic solvent was then removed
  4. customthe solid was collected
  5. filtrationafter filtration to the title compound (350 mg, 91%)

Sources & evidence

ORD record
ord-663fe5e2ba774f4da8bf8419297ae0a0
Source dataset
uspto-grants-2008_10
Patent number
US07439246B2

Reaction notes

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