Thionyl Chloride → 3,4-Difluorobenzenepropanoyl chloride

HRID 2117262Notes

Reaction equation

HRID 2117262 reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[F:13])[CH:5]=[CH:6][C:7](O)=[O:8].S(Cl)([Cl:16])=O>ClC(Cl)C.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]([Cl:16])=[O:8])[CH:10]=[CH:11][C:12]=1[F:13]

Participants

5

Reactant 2

HCID 24386Thionyl Chloride

HCID 1454863-(3,4-Difluorophenyl)prop-2-enoic acid

Product 1

HCID 575859753,4-Difluorobenzenepropanoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalyst

HCID 63651,1-DichloroethaneSolvent

Procedure

To 0.27 mol of 3,4-difluorocinnamic acid dissolved in dichloroethane there are added 20 drops of dimethylformamide and 100 ml of thionyl chloride.

Sources & evidence

ORD record: ord-e7d404ec0d5e4f63875cfd8f341b6cf5
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07442692B2

Reaction notes

Loading…